Dermatology Guide - Systemic Disease

Dermatological Skin Signs in Systemic Diseases

• Immune, Autoimmune, Rheumatic Diseases (urticaria, angioedema, systemic amyloidosis, dermatomyositis, dermatitis herpetiformis, erythema multiforme syndrome, erythema nodosum syndrome, levido reticularis, lupus erythematosus, graft-versus-host disease, systemic lupus erythematosus (SLE), cutaneous lupus erythematosus, scleroderma, Raynaud's disease, vasculitis, Reiter's syndrome, pyoderma gangrenosum, bullous pemphigoid, pemphigus vulgaris, sarcoidosis)

• Genetic, Metabolic, Endocrine and Nutritional Diseases (necrobiosis lipoidica and calciphylaxis associated with diabetes mellitus, hereditary hemorrhagic telangiectasia, hyperthyroidism, hypothyroidism and myxedema, scurvy, tuberous scerosis, neurofibromatosis, xanthomas, Cushing's syndrome)

• Vascular Insufficiency (chronic venous insufficiency, leg ulcers, pressure ulcers)

• Skin Signs of Systemic Cancers (Acanthosis Nigricans, Peutz-Jeghers Syndrome, mammary paget's disease, extramammary paget's disease, Cowden's syndrome, metastatic cancers to the skin

• Hematological Disease (thrombocytopenic purpura, disseminated intravascular coagulation)

• Cutaneous Lymphomas, Leukemias etc (adult T-cell leukemia/lymphoma, cutaneous T-cell lymphoma, cutaneous B-cell lymphoma, langerhans cell histiocytosis, mastocytosis syndromes etc)

• Adverse Drug Reactions (fixed drug eruption, Stevens-Johnson Syndrome, Toxis Epidermal Necrolysis, urticaria, angioedema, exanthematous drug eruption, necrosis from warfarin, drug-induced pigmentation)